Chemiosmotic Coupling: Protons fast and slow

Proton - coupled Energy Transducti on by Biological Membranes Principles , Pathways and Praxis BY DOUGLAS

A brief outline of certain features of the chemiosmotic hypothesis of the mechanism of free-energy transfer between the reactions of electron transport and adenosine triphosphate synthesis catalysed by biological membranes is given. Pulses of electron transport induced by the addition of small quantities of oxygen to suspensions of the bacterium Paracoccus denitrifcans lead to vectorial H+ move...

Oxygen-pulse curves in rat liver mitochondrial suspensions. Some observations and deductions.

1. The inference, implicit in the chemiosmotic hypothesis, that protons move into the bulk phase during ATP synthesis was investigated. 2. Incubation of rat liver mitochondria in the presence of the cation exchanger CM-Sephadex C-50 caused alkalinization in the medium, though total ATP synthesis remained unchanged. The addition of N-ethylmaleimide prevented the alkalinization, but there was sti...

On the functional proton current pathway of electron transport phosphorylation. An electrodic view.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I . Introduction * . . . . . . . . . . . . . . . . . . . I1 . Protonic coupling in electron transport phosphorylation . . . . . . . . . . . . . . . A . Background: the chemiosmotic and local proton hypotheses B . Some recent experimental work concerned with the measurement of Ap . . . . . . . . 1 . Results f...

Effects Of Fast Pathway Ablation On The Concealment Zone And Electrophysiological Behavior Of AV-Node During Atrial Fibrillation.

Objectives: Dual pathways have a determinant role in the occurrence of atrio nodal tachyarrhythmia (AVNRT). The aim of present study is to determine the role of slow pathway (SP) in the concealment zone and protective role of AV node during atrial fibrillation (AF). Material &Methods: In 7 isolated nodal rabbit preparation zone of concealment and concealed conduction is quantified by Specif...

Chemiosmotic Coupling: Power Transmission by Proticity